Pop!_OS 20.10 is based on Ubuntu 20.10 and includes the latest GNOME 3.38 release, Linux 5.8, and many other updates. For more information, see the Pop!_OS 20.10 release blog post.
You can choose to upgrade from Pop!_OS 20.04 LTS. 20.04 is an LTS that will continue to receive maintenance for a while, but will have a number of older packages. To upgrade, first make sure to install all updates in Pop!_Shop or using apt-get on the command line. You should receive an upgrade notification the next time you log in. If you do not, make sure you are up to date and reboot the system.
To perform a clean installation, download one of the ISOs from the Pop!_OS website. It is recommended to use the NVIDIA ISO when you have an NVIDIA GPU.
If you have issues, feel free to comment on this post or create an issue on the main Pop!_OS GitHub repository